Human macrophage activation programs induced by bacterial pathogens

Understanding the response of innate immune cells to pathogens may provide insights to host defenses and the tactics used by pathogens to circumvent these defenses. We used DNA microarrays to explore the responses of human macrophages to a variety of bacteria. Macrophages responded to a broad range of bacteria with a robust, shared pattern of gene expression. The shared response includes genes encoding receptors, signal transduction molecules, and transcription factors. This shared activation program transforms the macrophage into a cell primed to interact with its environment and to mount an immune response. Further study revealed that the activation program is induced by bacterial components that are…

• BS
  Bristol-Myers Squibb
• MG
  Massachusetts General Hospital
• UO
  University of Missouri
• CS
  Colorado State University
• UO
  University of Oklahoma
• UO
  University of Missouri-Kansas City
• NI
  National Institutes of Health
• UO
  University of Oklahoma Health Sciences Center
• TO
  Takeda Oncology
• NI
  National Institute of Allergy and Infectious Diseases