articleProceedings of the National Academy of SciencesJun 14, 2010GREEN OA

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

HYHuan YangHSHulda S. HreggvidsdottirKPKarin PalmbladHWHaichao WangMOMahendar Ochani

Feinstein Institute for Medical Research · Karolinska Institutet · +3 more institutions

PubMed
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Abstract

During infection, vertebrates develop "sickness syndrome," characterized by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and inflammation. These pathophysiological responses are mediated by cytokines, including TNF and IL-1, released during the innate immune response to invasion. Even in the absence of infection, qualitatively similar physiological syndromes occur following sterile injury, ischemia reperfusion, crush injury, and autoimmune-mediated tissue damage. Recent advances implicate high-mobility group box 1 (HMGB1), a nuclear protein with inflammatory cytokine activities, in stimulating cytokine release. HMGB1 is passively released during cell injury and necrosis, or actively…

Citation impact

811
total citations
FWCI
31.31
Percentile
100%
References
30
Citations per year

Authors

15

Topics & keywords

Topics
Keywords
  • HMGB1
  • Cytokine
  • TLR4
  • Inflammation
  • Innate immune system
  • Immunology
  • Toll-like receptor
  • Tumor necrosis factor alpha
UN Sustainable Development Goals
  • Good health and well-being
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