Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Spanish National Centre for Cardiovascular Research · Spanish National Centre for Cardiovascular Research · +1 more institution
Abstract
The immune synapse is an exquisitely evolved means of communication between T cells and antigen-presenting cells (APCs) during antigen recognition. Recent evidence points to the transfer of RNA via exosomes as a novel mode of intercellular communication. Here we show that exosomes of T, B and dendritic immune cells contain microRNA (miRNA) repertoires that differ from those of their parent cells. We investigate whether miRNAs are exchanged during cognate immune interactions, and demonstrate the existence of antigen-driven unidirectional transfer of miRNAs from the T cell to the APC, mediated by the delivery of CD63+ exosomes on immune synapse formation. Inhibition of exosome production by targeting neutral…
Citation impact
- FWCI
- 41.90
- Percentile
- 100%
- References
- 61
Authors
8- MMMarı́a Mittelbrunn
Spanish National Centre for Cardiovascular Research, Spanish National Centre for Cardiovascular Research
- CGCristina Gutiérrez‐Vázquez
Spanish National Centre for Cardiovascular Research
- CVCarolina Villarroya‐Beltri
Spanish National Centre for Cardiovascular Research
- SGSusana González
Spanish National Centre for Cardiovascular Research
- FSFátima Sánchez‐Cabo
Spanish National Centre for Cardiovascular Research
Topics & keywords
- Microvesicles
- Immune system
- Cell biology
- microRNA
- Biology
- Antigen
- Immunological synapse
- Antigen-presenting cell