reviewNature Reviews Drug DiscoveryDec 1, 2010Closed access

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

DADennis A. SmithLDLi DiEHEdward H. Kerns

Pfizer (United States)

PubMed
Indexed incrossrefpubmed

Abstract

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Citation impact

880
total citations
FWCI
14.70
Percentile
100%
References
92
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • In vivo
  • Drug discovery
  • Drug
  • Free fraction
  • Pharmacology
  • Plasma protein binding
  • Chemistry
  • In vitro
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