Cumulative Association of Five Genetic Variants with Prostate Cancer
Wake Forest University · Karolinska Institutet · +4 more institutions
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Abstract
Background
Single-nucleotide polymorphisms (SNPs) in five chromosomal regions--three at 8q24 and one each at 17q12 and 17q24.3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger.
Methods
We evaluated 16 SNPs from five chromosomal regions in a Swedish population (2893 subjects with prostate cancer and 1781 control subjects) and assessed the individual and combined association of the SNPs with prostate cancer.
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633
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- FWCI
- 76.40
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- 100%
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- 16
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Authors
21Topics & keywords
Topics
Keywords
- Medicine
- Prostate cancer
- Prostate
- Cancer
- Oncology
- Genetic variants
- Genetics
- Internal medicine
UN Sustainable Development Goals
- Good health and well-being
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