Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities
University of Iowa · Veterans Health Administration · +2 more institutions
Abstract
Given their essential function in aerobic metabolism, mitochondria are intuitively of interest in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional perturbations in mitochondria have been identified and affect the cause and complications of diabetes. Moreover, as a consequence of fuel oxidation, mitochondria generate considerable reactive oxygen species (ROS). Evidence is accumulating that these radicals per se are important in the pathophysiology of diabetes and its complications. In this review, we first present basic concepts underlying mitochondrial physiology. We then address mitochondrial function and ROS as related to diabetes. We consider different forms of diabetes…
Citation impact
- FWCI
- 10.17
- Percentile
- 100%
- References
- 362
Authors
2- WIWilliam I. SivitzCorresponding
University of Iowa, Veterans Health Administration, Iowa City VA Medical Center, Iowa Diabetes and Endocrinology Research Center
- MAMark A. Yorek
University of Iowa, Veterans Health Administration, Iowa City VA Medical Center, Iowa Diabetes and Endocrinology Research Center
Topics & keywords
- Mitochondrion
- Diabetes mellitus
- Reactive oxygen species
- Type 2 diabetes
- Pathophysiology
- Biology
- Insulin resistance
- Insulin
- Good health and well-being