MicroRNAs in cell proliferation, cell death, and tumorigenesis
HHH-W HwangJTJoshua T. Mendell
Johns Hopkins University · Johns Hopkins Medicine
Indexed incrossrefpubmed
Abstract
MicroRNAs (miRNAs) are a recently discovered class of approximately 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
Citation impact
1,404
total citations
- FWCI
- 18.18
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- 100%
- References
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Authors
2- HHH-W HwangCorresponding
Johns Hopkins University, Johns Hopkins Medicine
- JTJoshua T. Mendell
Johns Hopkins University, Johns Hopkins Medicine
Topics & keywords
Topics
Keywords
- microRNA
- Carcinogenesis
- Multicellular organism
- Biology
- Suppressor
- Cell growth
- Programmed cell death
- Cell biology
UN Sustainable Development Goals
- Good health and well-being
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