miR‐15b and miR‐16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells
Zero to Three · Xijing Hospital · +1 more institution
Abstract
MicroRNAs are endogenous small noncoding RNAs that regulate gene expression negatively at posttranscriptional level. This latest addition to the complex gene regulatory circuitry revolutionizes our way to understanding physiological and pathological processes in the human body. Here we investigated the possible role of microRNAs in the development of multidrug resistance (MDR) in gastric cancer cells. microRNA expression profiling revealed a limited set of microRNAs with altered expression in multidrug- resistant gastric cancer cell line SGC7901/VCR compared to its parental SGC7901 cell line. Among the downregulated microRNAs are miR-15b and miR-16, members of miR-15/16 family, whose expression was further…
Citation impact
- FWCI
- 19.18
- Percentile
- 100%
- References
- 47
Authors
9- LXLin Xia
Zero to Three, Xijing Hospital, Air Force Medical University
- DZDexin Zhang
Zero to Three, Xijing Hospital, Air Force Medical University
- RDRui Du
Zero to Three, Xijing Hospital, Air Force Medical University
- YPYanglin Pan
Xijing Hospital, Air Force Medical University
- LZLina Zhao
Xijing Hospital, Air Force Medical University
Topics & keywords
- microRNA
- Downregulation and upregulation
- Multiple drug resistance
- Cancer research
- Cancer cell
- Biology
- Transfection
- Untranslated region
- Good health and well-being