Pulmonary Alveolar Proteinosis
Cincinnati Children's Hospital Medical Center · Saitama International Medical Center
Indexed incrossrefpubmed
Abstract
In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar macrophages require granulocyte–macrophage colony-stimulating factor (GM-CSF) to perform this function. Autoantibodies against GM-CSF may cause pulmonary alveolar proteinosis.
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788
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Authors
3Topics & keywords
Topics
Keywords
- Pulmonary alveolar proteinosis
- Medicine
- Alveolar macrophage
- Granulocyte macrophage colony-stimulating factor
- Pulmonary alveolus
- Pathology
- Granulocyte
- Macrophage
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