Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
University of Toronto · Great Ormond Street Hospital · +10 more institutions
Abstract
DNA methylation, an important type of epigenetic modification in humans, participates in crucial cellular processes, such as embryonic development, X-inactivation, genomic imprinting and chromosome stability. Several platforms have been developed to study genome-wide DNA methylation. Many investigators in the field have chosen the Illumina Infinium HumanMethylation microarray for its ability to reliably assess DNA methylation following sodium bisulfite conversion. Here, we analyzed methylation profiles of 489 adult males and 357 adult females generated by the Infinium HumanMethylation450 microarray. Among the autosomal CpG sites that displayed significant methylation differences between the two sexes, we…
Citation impact
- FWCI
- 43.97
- Percentile
- 100%
- References
- 17
Authors
9- YAY. Ann Chen
University of Toronto, Great Ormond Street Hospital, Hospital for Sick Children, Institut thématique Génétique, génomique et bioinformatique, SickKids Foundation, University College London
- MLMathieu Lemire
Ontario Institute for Cancer Research
- SCSanaa Choufani
Great Ormond Street Hospital, Hospital for Sick Children, Institut thématique Génétique, génomique et bioinformatique, SickKids Foundation, University College London
- DTDarci T. Butcher
Great Ormond Street Hospital, Hospital for Sick Children, Institut thématique Génétique, génomique et bioinformatique, SickKids Foundation, University College London
- DGDaria Grafodatskaya
Great Ormond Street Hospital, Hospital for Sick Children, Institut thématique Génétique, génomique et bioinformatique, SickKids Foundation, University College London
Topics & keywords
- Biology
- DNA methylation
- Illumina Methylation Assay
- Genetics
- Methylation
- Epigenetics
- Microarray
- DNA microarray