Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
University of North Carolina at Chapel Hill · UNC Lineberger Comprehensive Cancer Center · +1 more institution
Abstract
Human genome-wide association studies have linked single nucleotide polymorphisms (SNPs) on chromosome 9p21.3 near the INK4/ARF (CDKN2a/b) locus with susceptibility to atherosclerotic vascular disease (ASVD). Although this locus encodes three well-characterized tumor suppressors, p16(INK4a), p15(INK4b), and ARF, the SNPs most strongly associated with ASVD are ∼120 kb from the nearest coding gene within a long non-coding RNA (ncRNA) known as ANRIL (CDKN2BAS). While individuals homozygous for the atherosclerotic risk allele show decreased expression of ANRIL and the coding INK4/ARF transcripts, the mechanism by which such distant genetic variants influence INK4/ARF expression is unknown. Here, using rapid…
Citation impact
- FWCI
- 8.56
- Percentile
- 100%
- References
- 83
Authors
6- CEChristin E. Burd
University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center
- WRWilliam R. Jeck
University of North Carolina at Chapel Hill
- YLYan Liu
University of North Carolina at Chapel Hill
- HKHanna K. Sanoff
University of Virginia
- ZWZefeng Wang
University of North Carolina at Chapel Hill
Topics & keywords
- Biology
- Locus (genetics)
- Genetics
- RNA
- Exon
- RNA splicing
- Gene
- Single-nucleotide polymorphism