Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Howard Hughes Medical Institute · Johns Hopkins University · +4 more institutions
Abstract
More than 2% of the adult U.S. population harbors a pancreatic cyst. These often pose a difficult management problem because conventional criteria cannot always distinguish cysts with malignant potential from those that are innocuous. One of the most common cystic neoplasms of the pancreas, and a bona fide precursor to invasive adenocarcinoma, is called intraductal papillary mucinous neoplasm (IPMN). To help reveal the pathogenesis of these lesions, we purified the DNA from IPMN cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. In addition to the expected KRAS mutations, we identified recurrent mutations at codon 201 of GNAS. A larger number (113) of…
Citation impact
- FWCI
- 27.68
- Percentile
- 100%
- References
- 66
Authors
19- JWJian WuCorresponding
Howard Hughes Medical Institute, Johns Hopkins University, Sidney Kimmel Cancer Center
- HMHanno Matthaei
Johns Hopkins University, Cancer Research Center
- AMAnirban Maitra
Johns Hopkins University, Cancer Research Center
- MDMarco Dal Molin
Johns Hopkins University, Cancer Research Center
- LDLaura D. Wood
Johns Hopkins University, Cancer Research Center
Topics & keywords
- GNAS complex locus
- KRAS
- Cyst
- Pancreas
- Medicine
- Intraductal papillary mucinous neoplasm
- Adenocarcinoma
- Pathology
- Good health and well-being