Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication
Centre National de la Recherche Scientifique · National Institutes of Health · +5 more institutions
Abstract
MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that function as gene regulators and as a host cell defense against both RNA and DNA viruses. We provide evidence for a physiological role of the miRNA-silencing machinery in controlling HIV-1 replication. Type III RNAses Dicer and Drosha, responsible for miRNA processing, inhibited virus replication both in peripheral blood mononuclear cells from HIV-1-infected donors and in latently infected cells. In turn, HIV-1 actively suppressed the expression of the polycistronic miRNA cluster miR-17/92. This suppression was found to be required for efficient viral replication and was dependent on the histone acetyltransferase Tat cofactor…
Citation impact
- FWCI
- 23.51
- Percentile
- 100%
- References
- 22
Authors
14- RTRobinson Triboulet
Centre National de la Recherche Scientifique, National Institutes of Health, Hôpital Gui de Chauliac, Institut de Génétique Moléculaire de Montpellier, National Institute of Allergy and Infectious Diseases, Institut de Pharmacologie Moléculaire et Cellulaire, Institut de Génétique Humaine
- BMBernard Mari
Centre National de la Recherche Scientifique, National Institutes of Health, Hôpital Gui de Chauliac, Institut de Génétique Moléculaire de Montpellier, National Institute of Allergy and Infectious Diseases, Institut de Pharmacologie Moléculaire et Cellulaire, Institut de Génétique Humaine
- YLYea‐Lih Lin
Centre National de la Recherche Scientifique, National Institutes of Health, Hôpital Gui de Chauliac, Institut de Génétique Moléculaire de Montpellier, National Institute of Allergy and Infectious Diseases, Institut de Pharmacologie Moléculaire et Cellulaire, Institut de Génétique Humaine
- CCChristine Chable-Bessia
Centre National de la Recherche Scientifique, National Institutes of Health, Hôpital Gui de Chauliac, Institut de Génétique Moléculaire de Montpellier, National Institute of Allergy and Infectious Diseases, Institut de Pharmacologie Moléculaire et Cellulaire, Institut de Génétique Humaine
- YBYamina Bennasser
Centre National de la Recherche Scientifique, National Institutes of Health, Hôpital Gui de Chauliac, Institut de Génétique Moléculaire de Montpellier, National Institute of Allergy and Infectious Diseases, Institut de Pharmacologie Moléculaire et Cellulaire, Institut de Génétique Humaine
Topics & keywords
- Drosha
- Gene silencing
- Dicer
- Biology
- microRNA
- Viral replication
- RNA-induced silencing complex
- Argonaute
- Good health and well-being