Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
University of California San Diego · Konkuk University · +2 more institutions
Abstract
Neuronal accumulation of alpha-synuclein and Lewy body formation are characteristic to many neurodegenerative diseases, including Parkinson's disease (PD). This Lewy pathology appears to spread throughout the brain as the disease progresses. Furthermore, recent studies showed the occurrence of Lewy pathology in neurons grafted into the brains of PD patients, suggesting the spread of pathology from the host tissues to the grafts. The mechanism underlying this propagation is unknown. Here, we show that alpha-synuclein is transmitted via endocytosis to neighboring neurons and neuronal precursor cells, forming Lewy-like inclusions. Moreover, alpha-synuclein was transmitted from the affected neurons to engrafted…
Citation impact
- FWCI
- 54.95
- Percentile
- 100%
- References
- 32
Authors
9- PDPaula DesplatsCorresponding
University of California San Diego
- HLHe-Jin Lee
Konkuk University, Institute of Biomedical Science
- EBEun-Jin Bae
Konkuk University Medical Center, Institute of Biomedical Science
- CPChristina Patrick
University of California San Diego
- EREdward Rockenstein
University of California San Diego
Topics & keywords
- Lewy body
- Neuron
- Biology
- Alpha-synuclein
- Parkinson's disease
- Neuroscience
- Programmed cell death
- Neurodegeneration
- Good health and well-being