articleProceedings of the National Academy of SciencesNov 14, 2012GREEN OA

Strong signatures of selection in the domestic pig genome

CRCarl‐Johan RubinHMHendrik‐Jan MegensÁMÁlvaro Martínez BarrioKMKhurram MaqboolSSShumaila Sayyab

Uppsala University · Science for Life Laboratory · +5 more institutions

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Abstract

Domestication of wild boar (Sus scrofa) and subsequent selection have resulted in dramatic phenotypic changes in domestic pigs for a number of traits, including behavior, body composition, reproduction, and coat color. Here we have used whole-genome resequencing to reveal some of the loci that underlie phenotypic evolution in European domestic pigs. Selective sweep analyses revealed strong signatures of selection at three loci harboring quantitative trait loci that explain a considerable part of one of the most characteristic morphological changes in the domestic pig--the elongation of the back and an increased number of vertebrae. The three loci were associated with the NR6A1, PLAG1, and LCORL genes. The…

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Topics & keywords

Topics
Keywords
  • Selection (genetic algorithm)
  • Genome
  • Biology
  • Evolutionary biology
  • Computational biology
  • Genetics
  • Computer science
  • Artificial intelligence
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