PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
Harvard University · Veneto Institute of Molecular Medicine · +4 more institutions
Abstract
Maintaining muscle size and fiber composition requires contractile activity. Increased activity stimulates expression of the transcriptional coactivator PGC-1alpha (peroxisome proliferator-activated receptor gamma coactivator 1alpha), which promotes fiber-type switching from glycolytic toward more oxidative fibers. In response to disuse or denervation, but also in fasting and many systemic diseases, muscles undergo marked atrophy through a common set of transcriptional changes. FoxO family transcription factors play a critical role in this loss of cell protein, and when activated, FoxO3 causes expression of the atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 and profound loss of muscle mass. To…
Citation impact
- FWCI
- 13.22
- Percentile
- 100%
- References
- 54
Authors
8- MSMarco SandriCorresponding
Harvard University, Veneto Institute of Molecular Medicine, Dulbecco Telethon Institute
- JDJiandie D. Lin
Harvard University, University of Michigan, Dana-Farber Cancer Institute
- CHChristoph Handschin
Harvard University, Dana-Farber Cancer Institute
- WYWenli Yang
Harvard University, Dana-Farber Cancer Institute
- ZAZoltàn Arany
Harvard University, Dana-Farber Cancer Institute
Topics & keywords
- Denervation
- Atrophy
- FOXO3
- Muscle atrophy
- Endocrinology
- Internal medicine
- Biology
- Skeletal muscle