Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
Johns Hopkins University · University of California, Irvine · +1 more institution
Abstract
Pattern separation, the process of transforming similar representations or memories into highly dissimilar, nonoverlapping representations, is a key component of many functions ascribed to the hippocampus. Computational models have stressed the role of the hippocampus and, in particular, the dentate gyrus and its projections into the CA3 subregion in pattern separation. We used high-resolution (1.5-millimeter isotropic voxels) functional magnetic resonance imaging to measure brain activity during incidental memory encoding. Although activity consistent with a bias toward pattern completion was observed in CA1, the subiculum, and the entorhinal and parahippocampal cortices, activity consistent with a strong…
Citation impact
- FWCI
- 19.52
- Percentile
- 100%
- References
- 23
Authors
4- ABArnold Bakker
Johns Hopkins University, University of California, Irvine, University of California San Diego
- CBC. Brock Kirwan
Johns Hopkins University, University of California, Irvine, University of California San Diego
- MIMichael I. Miller
Johns Hopkins University, University of California, Irvine, University of California San Diego
- CECraig E.L. StarkCorresponding
Johns Hopkins University, University of California, Irvine, University of California San Diego
Topics & keywords
- Dentate gyrus
- Subiculum
- Hippocampal formation
- Entorhinal cortex
- Parahippocampal gyrus
- Neuroscience
- Hippocampus
- Limbic lobe