reviewStem CellsDec 4, 2009BRONZE OA

Mesenchymal Stromal Cells: Current Understanding and Clinical Status

HKHusein K. SalemCTChristoph Thiemermann

Queen Mary University of London · William Harvey Research Institute

PubMed
Indexed incrossrefpubmed

Abstract

Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the potential to give rise to cells of diverse lineages. Numerous studies have reported beneficial effects of MSCs in tissue repair and regeneration. After culture expansion and in vivo administration, MSCs home to and engraft to injured tissues and modulate the inflammatory response through synergistic downregulation of proinflammatory cytokines and upregulation of both prosurvival and antiinflammatory factors. In addition, MSCs possess remarkable immunosuppressive properties, suppressing T-cell, NK cell functions, and also…

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923
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Authors

2

Topics & keywords

Topics
Keywords
  • Biology
  • Mesenchymal stem cell
  • Stromal cell
  • Computational biology
  • Cell biology
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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