Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia
Marine Biological Laboratory · University of Arizona · +4 more institutions
Abstract
The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways. Protein kinases comprise the single largest protein class and reflect Giardia's requirement for a complex signal transduction network for coordinating differentiation. Lateral gene transfer from bacterial and archaeal donors has shaped Giardia's genome, and previously unknown gene families, for example, cysteine-rich structural proteins, have been discovered. Unexpectedly, the genome shows little evidence of heterozygosity,…
Citation impact
- FWCI
- 42.95
- Percentile
- 100%
- References
- 42
Authors
29- HGHilary G. MorrisonCorresponding
Marine Biological Laboratory, University of Arizona, University of Illinois Urbana-Champaign, The University of Texas at El Paso, University of California System, University of California San Diego
- AGAndrew G. McArthur
Marine Biological Laboratory, University of Arizona, University of Illinois Urbana-Champaign, The University of Texas at El Paso, University of California System, University of California San Diego
- FDFrances D. Gillin
Marine Biological Laboratory, University of Arizona, University of Illinois Urbana-Champaign, The University of Texas at El Paso, University of California System, University of California San Diego
- SBStephen B. Aley
Marine Biological Laboratory, University of Arizona, University of Illinois Urbana-Champaign, The University of Texas at El Paso, University of California System, University of California San Diego
- RDRodney D. Adam
Marine Biological Laboratory, University of Arizona, University of Illinois Urbana-Champaign, The University of Texas at El Paso, University of California System, University of California San Diego
Topics & keywords
- Giardia lamblia
- Biology
- Genome
- Giardia
- Genetics
- Gene
- Protist
- Intron