Mapping the Antigenic and Genetic Evolution of Influenza Virus
Los Alamos National Laboratory · University of Cambridge · +2 more institutions
Abstract
The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population…
Citation impact
- FWCI
- 20.55
- Percentile
- 100%
- References
- 31
Authors
7- DJDerek J. SmithCorresponding
Los Alamos National Laboratory, University of Cambridge, National Influenza Center, Erasmus University Rotterdam
- ASAlan S. LapedesCorresponding
Los Alamos National Laboratory, University of Cambridge, National Influenza Center, Erasmus University Rotterdam
- JDJ.C. de Jong
Los Alamos National Laboratory, University of Cambridge, National Influenza Center, Erasmus University Rotterdam
- TMTheo M. Bestebroer
Los Alamos National Laboratory, University of Cambridge, National Influenza Center, Erasmus University Rotterdam
- GFGuus F. Rimmelzwaan
Los Alamos National Laboratory, University of Cambridge, National Influenza Center, Erasmus University Rotterdam
Topics & keywords
- Antigenic drift
- Antigenic shift
- Biology
- Virus
- Antigen
- Virology
- Antigenic variation
- Viral evolution
- Good health and well-being