articleProceedings of the National Academy of SciencesApr 23, 2012BRONZE OA

Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems

CBClaudia BußEPElysia Poggi DavisBSBabak ShahbabaJCJens C. PruessnerKHKevin Head

University of California, Irvine · McGill University

PubMed
Indexed incrossrefpubmed

Abstract

Stress-related variation in the intrauterine milieu may impact brain development and emergent function, with long-term implications in terms of susceptibility for affective disorders. Studies in animals suggest limbic regions in the developing brain are particularly sensitive to exposure to the stress hormone cortisol. However, the nature, magnitude, and time course of these effects have not yet been adequately characterized in humans. A prospective, longitudinal study was conducted in 65 normal, healthy mother-child dyads to examine the association of maternal cortisol in early, mid-, and late gestation with subsequent measures at approximately 7 y age of child amygdala and hippocampus volume and affective…

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Topics & keywords

Topics
Keywords
  • Amygdala
  • Hippocampus
  • Psychology
  • Gestation
  • Affect (linguistics)
  • Pregnancy
  • Longitudinal study
  • Hormone
UN Sustainable Development Goals
  • Good health and well-being
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