Loss of Intranetwork and Internetwork Resting State Functional Connections with Alzheimer's Disease Progression

Alzheimer's disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in AD severity from unaffected [clinical…

• BS
  Bristol-Myers Squibb
• P
  Pfizer
• AR
  Avid Radiopharmaceuticals
• CF
  Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis
• NI
  National Institute of Mental Health

  Awards: K23MH081786, P30NS048056
• NI
  National Institute of Nursing Research

  Awards: R01NR012657, R01NR012907