Responsive Hydrogels from the Intramolecular Folding and Self-Assembly of a Designed Peptide
Biotechnology Institute · University of Delaware
Abstract
A general peptide design is presented that links the pH-dependent intramolecular folding of beta-hairpin peptides to their propensity to self-assemble, affording hydrogels rich in beta-sheet. Chemical responsiveness has been specifically engineered into the material by linking intramolecular folding to changes in solution pH, and mechanical responsiveness, by linking hydrogelation to self-assembly. Circular dichroic and infrared spectroscopies show that at low pH individual peptides are unstructured, affording a low-viscosity aqueous solution. Under basic conditions, intramolecular folding takes place, affording amphiphilic beta-hairpins that intermolecularly self-assemble. Rheology shows that the resulting…
Citation impact
- FWCI
- 14.25
- Percentile
- 100%
- References
- 55
Authors
6- JPJoel P. SchneiderCorresponding
Biotechnology Institute, University of Delaware
- DJDarrin J. Pochan
Biotechnology Institute, University of Delaware
- BOBulent Ozbas
University of Delaware, Biotechnology Institute
- KRKarthikan Rajagopal
University of Delaware, Biotechnology Institute
- LPLisa Pakstis
Biotechnology Institute, University of Delaware
Topics & keywords
- Intramolecular force
- Chemistry
- Self-healing hydrogels
- Folding (DSP implementation)
- Self-assembly
- Amphiphile
- Microscale chemistry
- Peptide
- Clean water and sanitation