Selective difluoromethylation and monofluoromethylation reactions

The selective introduction of fluorine atom(s) and fluorinated moieties into organic molecules has become an important and fast-growing research field, since fluorine atoms play crucial roles in life science and materials science-related applications. Similar to the trifluoromethyl group, both difluoromethyl and monofluoromethyl groups can often bring about many beneficial effects to the target molecules, and a variety of CF(2)H- and CH(2)F-containing pharmaceuticals and agrochemicals have been developed. Among the synthetic methods for CF(2)H- and CH(2)F-containing compounds, selective di- and monofluoromethylation (i.e., introduction of CF(2)H and CH(2)F groups into organic molecules) represent one of the…

• NS
  National Science Foundation
• NN
  National Natural Science Foundation of China