Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles
Chinese Academy of Sciences · Shanghai Institute of Ceramics
Abstract
Most present nanodrug delivery systems have been developed to target cancer cells but rarely nuclei. However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time. Monodispersed MSNs-TAT of varied particle sizes have been synthesized to investigate the effects of particle size and TAT conjugation on the nuclear membrane penetrability of MSNs. MSNs-TAT with a diameter of 50 nm or smaller can efficiently target the nucleus and deliver the active anticancer drug doxorubicin (DOX) into the targeted…
Citation impact
- FWCI
- 31.98
- Percentile
- 100%
- References
- 37
Authors
7- LPLimin PanCorresponding
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- QHQianjun He
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- JLJianan Liu
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- YCYu Chen
Chinese Academy of Sciences, Shanghai Institute of Ceramics
- MMMing Ma
Chinese Academy of Sciences, Shanghai Institute of Ceramics
Topics & keywords
- Mesoporous silica
- Chemistry
- Doxorubicin
- Drug delivery
- Conjugate
- Targeted drug delivery
- Cancer cell
- Nanoparticle
- Good health and well-being