Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients With Coronary Artery Disease
Georgia Institute of Technology · University of Washington · +1 more institution
Abstract
BACKGROUND: Experimental studies suggest that low wall shear stress (WSS) promotes plaque development and high WSS is associated with plaque destabilization. We hypothesized that low-WSS segments in patients with coronary artery disease develop plaque progression and high-WSS segments develop necrotic core progression with fibrous tissue regression. METHODS AND RESULTS: Twenty patients with coronary artery disease underwent baseline and 6-month radiofrequency intravascular ultrasound (virtual histology intravascular ultrasound) and computational fluid dynamics modeling for WSS calculation. For each virtual histology intravascular ultrasound segment (n=2249), changes in plaque area, virtual histology…
Citation impact
- FWCI
- 31.12
- Percentile
- 100%
- References
- 66
Authors
9- HSHabib SamadyCorresponding
Georgia Institute of Technology, University of Washington, The Wallace H. Coulter Department of Biomedical Engineering
- PEParham Eshtehardi
Georgia Institute of Technology, University of Washington, The Wallace H. Coulter Department of Biomedical Engineering
- MMMichael McDaniel
Georgia Institute of Technology, University of Washington, The Wallace H. Coulter Department of Biomedical Engineering
- JSJin Suo
Georgia Institute of Technology, University of Washington, The Wallace H. Coulter Department of Biomedical Engineering
- SSSaurabh S. Dhawan
Georgia Institute of Technology, University of Washington, The Wallace H. Coulter Department of Biomedical Engineering
Topics & keywords
- Medicine
- Cardiology
- Internal medicine
- Coronary artery disease
- Artery
- Shear stress
- Arterial wall
- Good health and well-being