Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections
University of Oxford · Jenner Institute · +5 more institutions
Abstract
Characterization of the immune responses induced in the initial stages of human immunodeficiency virus type 1 (HIV-1) infection is of critical importance for an understanding of early viral pathogenesis and prophylactic vaccine design. Here, we used sequential plasma samples collected during the eclipse and exponential viral expansion phases from subjects acquiring HIV-1 (or, for comparison, hepatitis B virus [HBV]or hepatitis C virus [HCV]) to determine the nature and kinetics of the earliest systemic elevations in cytokine and chemokine levels in each infection. Plasma viremia was quantitated over time, and levels of 30 cytokines and chemokines were measured using Luminex-based multiplex assays and…
Citation impact
- FWCI
- 19.07
- Percentile
- 100%
- References
- 49
Authors
12- ASAndrea Stacey
University of Oxford, Jenner Institute
- PJPhilip J. Norris
University of California, San Francisco, Blood Systems Research Institute
- QLQin Li
University of Washington, Fred Hutch Cancer Center
- EHE Haygreen
University of Oxford, Jenner Institute
- ETElizabeth Taylor
University of Oxford, Jenner Institute
Topics & keywords
- Viremia
- Immunology
- Biology
- Cytokine
- Chemokine
- Hepatitis B virus
- Virology
- Immune system
- Good health and well-being