Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone
National Institute of Infectious Diseases · Örebro University Hospital · +2 more institutions
Abstract
Recently, the first Neisseria gonorrhoeae strain (H041) that is highly resistant to the extended-spectrum cephalosporin (ESC) ceftriaxone, the last remaining option for empirical first-line treatment, was isolated. We performed a detailed characterization of H041, phenotypically and genetically, to confirm the finding, examine its antimicrobial resistance (AMR), and elucidate the resistance mechanisms. H041 was examined using seven species-confirmatory tests, antibiograms (30 antimicrobials), porB sequencing, N. gonorrhoeae multiantigen sequence typing (NG-MAST), multilocus sequence typing (MLST), and sequencing of ESC resistance determinants (penA, mtrR, penB, ponA, and pilQ). Transformation, using…
Citation impact
- FWCI
- 42.40
- Percentile
- 100%
- References
- 46
Authors
9Topics & keywords
- Neisseria gonorrhoeae
- Gonorrhea
- Ceftriaxone
- Neisseriaceae
- Microbiology
- Gonococcal infection
- Medicine
- Strain (injury)