The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind
Medical University of South Carolina · Ralph H. Johnson VA Medical Center
Abstract
Sphingosine 1-phosphate sphingomyelin sphingomyelinase ceramidase tumor necrosis factor glucosylceramide synthase serine palmitoyltransferase protein kinase C interleukin-1 diacylglycerol neutral sphingomyelinase Whereas regulated turnover of glycerolipids has been observed and studied for more than six decades, dogma has held sphingolipids to be mostly structural molecules with inert metabolism. If anything, investigation over the past 15 years or so has taught us that sphingolipid metabolism comprises a set of highly regulated pathways that serve to control the levels of individual molecules, their interconversions, and their function. Most notable of these bioactive molecules are the sphingoid bases,…
Citation impact
- FWCI
- 20.01
- Percentile
- 100%
- References
- 57
Authors
2Topics & keywords
- Ceramide
- Sphingolipid
- Sphingomyelin
- Sphingosine
- Lipid signaling
- Diacylglycerol kinase
- Lactosylceramide
- Ceramide synthase