reviewNew England Journal of MedicineOct 7, 2009GREEN OA

DNA Damage, Aging, and Cancer

JHJan H.J. Hoeijmakers

Erasmus MC · Erasmus University Rotterdam · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

This review gives an account of how the cell repairs DNA damage and presents evidence that DNA damage contributes to aging and cancer, with the outcome dependent on the type and number of lesions in DNA. Examples of accelerated aging syndromes associated with defects in DNA repair mechanisms are contrasted with cancers.

Citation impact

2,191
total citations
FWCI
37.91
Percentile
100%
References
78
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • DNA damage
  • Medicine
  • DNA repair
  • Cancer
  • DNA
  • Cancer research
  • Genetics
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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