articleGenomicsJul 13, 2007HYBRID OA

Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters

PPPriit PruunsildAKAnna KazantsevaTATamara AidKPKaia PalmTTTõnis Timmusk

Tallinn University of Technology

PubMed
Indexed incrossrefdoajpubmed

Abstract

Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of neurotrophins, has central roles in the development, physiology, and pathology of the nervous system. We have elucidated the structure of the human BDNF gene, identified alternative transcripts, and studied their expression in adult human tissues and brain regions. In addition, the transcription initiation sites for human BDNF transcripts were determined and the activities of BDNF promoters were analyzed in transient overexpression assays. Our results show that the human BDNF gene has 11 exons and nine functional promoters that are used tissue and brain-region specifically. Furthermore, noncoding natural antisense RNAs that…

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Authors

5

Topics & keywords

Topics
Keywords
  • Biology
  • Promoter
  • Exon
  • Alternative splicing
  • Neurotrophic factors
  • Brain-derived neurotrophic factor
  • Gene
  • Gene expression
UN Sustainable Development Goals
  • Good health and well-being
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