Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
Mayo Clinic in Arizona · Mayo Clinic · +2 more institutions
Abstract
Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF and reduced EF, yet no effective treatment has been identified. While early research focused on the importance of diastolic dysfunction in the pathophysiology of HFpEF, recent studies have revealed that multiple non-diastolic abnormalities in cardiovascular function also contribute. Diagnosis of HFpEF is frequently challenging and relies upon careful clinical evaluation, echo-Doppler cardiography, and invasive haemodynamic assessment. In this review, the principal mechanisms, diagnostic approaches, and clinical trials are…
Citation impact
- FWCI
- 29.98
- Percentile
- 100%
- References
- 155
Authors
2Topics & keywords
- Medicine
- Heart failure with preserved ejection fraction
- Cardiology
- Heart failure
- Ejection fraction
- Internal medicine
- Diastole
- Pathophysiology
- Good health and well-being