Characterization of the Peri-Infarct Zone by Contrast-Enhanced Cardiac Magnetic Resonance Imaging Is a Powerful Predictor of Post–Myocardial Infarction Mortality
Brigham and Women's Hospital · General Electric (United States) · +3 more institutions
Abstract
BACKGROUND: Accurate risk stratification is crucial for effective treatment planning after myocardial infarction (MI). Previous studies suggest that the peri-infarct border zone may be an important arrhythmogenic substrate. In this pilot study, we tested the hypothesis that the extent of the peri-infarct zone quantified by contrast-enhanced cardiac magnetic resonance (CMR) is an independent predictor of post-MI mortality. METHODS AND RESULTS: We studied 144 patients with documented coronary artery disease and abnormal myocardial delayed enhancement (MDE) consistent with MI. A computer-assisted, semiautomatic algorithm quantified the total infarct size and divided it into the core and peri-infarct regions based…
Citation impact
- FWCI
- 32.15
- Percentile
- 100%
- References
- 31
Authors
10- ATAndrew T. YanCorresponding
Brigham and Women's Hospital, General Electric (United States), Harvard University, University of Vermont Medical Center, Cardiovascular Research Center
- AJAdolphe J. Shayne
Brigham and Women's Hospital, General Electric (United States), Harvard University, University of Vermont Medical Center, Cardiovascular Research Center
- KAKenneth A. Brown
Brigham and Women's Hospital, General Electric (United States), Harvard University, University of Vermont Medical Center, Cardiovascular Research Center
- SGSandeep Gupta
Brigham and Women's Hospital, General Electric (United States), Harvard University, University of Vermont Medical Center, Cardiovascular Research Center
- CCCarmen Chan
Brigham and Women's Hospital, General Electric (United States), Harvard University, University of Vermont Medical Center, Cardiovascular Research Center
Topics & keywords
- Medicine
- Cardiology
- Internal medicine
- Myocardial infarction
- Hazard ratio
- Ejection fraction
- Magnetic resonance imaging
- Infarction
- Good health and well-being