articleProceedings of the National Academy of SciencesOct 19, 2010GREEN OA

Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

YKYasushi KojimaAAAhmet AcarENElinor Ng EatonKTKieran T. MellodyCSChristina Scheel

University of Manchester · Cancer Research UK Manchester Institute · +6 more institutions

PubMed
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Abstract

Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast carcinomas, include a large number of myofibroblasts, a hallmark of activated fibroblasts. These fibroblasts have an ability to substantially promote tumorigenesis. However, the precise cellular origins of CAFs and the molecular mechanisms by which these cells evolve into tumor-promoting myofibroblasts remain unclear. Using a coimplantation breast tumor xenograft model, we show that resident human mammary fibroblasts progressively convert into CAF myofibroblasts during the course of tumor…

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Topics & keywords

Topics
Keywords
  • Autocrine signalling
  • Stromal cell
  • Myofibroblast
  • Cancer research
  • Stroma
  • Tumor microenvironment
  • Tumor progression
  • Paracrine signalling
UN Sustainable Development Goals
  • Good health and well-being
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