Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons
University of Toronto · Sunnybrook Health Science Centre · +4 more institutions
Abstract
Cross-sectional studies suggest that sleep fragmentation is associated with cognitive performance in older adults. We tested the hypothesis that sleep fragmentation is associated with incident Alzheimer's disease (AD) and the rate of cognitive decline in older adults. Prospective cohort study. Community-based 737 community dwelling older adults without dementia. Sleep fragmentation was quantified from up to 10 consecutive days of actigraphy. Subjects underwent annual evaluation for AD with 19 neuropsychological tests. Over a follow-up period of up to 6 years (mean 3.3 years), 97 individuals developed AD. In a Cox proportional hazards model controlling for age, sex, and education, a higher level of sleep…
Citation impact
- FWCI
- 29.96
- Percentile
- 100%
- References
- 33
Authors
5- ALAndrew LimCorresponding
University of Toronto, Sunnybrook Health Science Centre, Health Sciences Centre
- MKMatthew Kowgier
University of Toronto, Ontario Institute for Cancer Research
- LYLei Yu
Rush University, Rush University Medical Center
- ASAron S. Buchman
Rush University, Rush University Medical Center
- DADavid A. Bennett
Rush University Medical Center, Rush University
Topics & keywords
- Actigraphy
- Dementia
- Medicine
- Cognitive decline
- Cohort
- Gerontology
- Fragmentation (computing)
- Confounding