Cathelicidins, multifunctional peptides of the innate immunity

Cathelicidins comprise a family of mammalian proteins containing a C-terminal cationic antimicrobial domain that becomes active after being freed from the N-terminal cathelin portion of the holoprotein. Many other members of this family have been identified since the first cathelicidin sequences were reported 10 years ago. The mature peptides generally show a wide spectrum of antimicrobial activity and, more recently, some of them have also been found to exert other biological activities. The human cathelicidin peptide LL-37 is chemotactic for neutrophils, monocytes, mast cells, and T cells; induces degranulation of mast cells; alters transcriptional responses in macrophages; stimulates wound vascularization…

• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca

  Award: P.R.I.N. Cofin. 2000 and 2002
• CF
  Center for Neuroscience Research

  Award: Agenzia 2000