C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring Study
Boston University · Harvard University · +5 more institutions
Abstract
BACKGROUND: Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. METHODS AND RESULTS: We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (> or =3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2,…
Citation impact
- FWCI
- 40.69
- Percentile
- 100%
- References
- 36
Authors
5- MKMartin K. RutterCorresponding
Boston University, Harvard University, University of Liverpool, University of Manchester, Massachusetts General Hospital, Framingham Heart Study, Countess of Chester Hospital
- JBJames B. Meigs
Boston University, Harvard University, University of Liverpool, University of Manchester, Massachusetts General Hospital, Framingham Heart Study, Countess of Chester Hospital
- LSLisa Sullivan
Boston University, Harvard University, University of Liverpool, University of Manchester, Massachusetts General Hospital, Framingham Heart Study, Countess of Chester Hospital
- RBRalph B. D’Agostino
Boston University, Harvard University, University of Liverpool, University of Manchester, Massachusetts General Hospital, Framingham Heart Study, Countess of Chester Hospital
- PWPeter W.F. Wilson
Boston University, Harvard University, University of Liverpool, University of Manchester, Massachusetts General Hospital, Framingham Heart Study, Countess of Chester Hospital
Topics & keywords
- Medicine
- Offspring
- Metabolic syndrome
- C-reactive protein
- Framingham Risk Score
- Internal medicine
- Framingham Heart Study
- Cardiology
- Gender equality