Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Délégation Paris 5 · Hôpital Necker-Enfants Malades · +6 more institutions
Abstract
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX(3)CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and…
Citation impact
- FWCI
- 35.13
- Percentile
- 100%
- References
- 27
Authors
10- CACédric Auffray
Délégation Paris 5, Hôpital Necker-Enfants Malades, Inserm, Institut Pasteur, Université Paris Cité, Institut Necker Enfants Malades, Assistance Publique – Hôpitaux de Paris, Institut de Pharmacologie Moléculaire et Cellulaire
- DKDarin K. Fogg
Délégation Paris 5, Hôpital Necker-Enfants Malades, Inserm, Institut Pasteur, Université Paris Cité, Institut Necker Enfants Malades, Assistance Publique – Hôpitaux de Paris, Institut de Pharmacologie Moléculaire et Cellulaire
- MGMeriem Garfa‐Traoré
Délégation Paris 5, Hôpital Necker-Enfants Malades, Inserm, Institut Pasteur, Université Paris Cité, Institut Necker Enfants Malades, Assistance Publique – Hôpitaux de Paris, Institut de Pharmacologie Moléculaire et Cellulaire
- GEGaëlle Elain
Délégation Paris 5, Hôpital Necker-Enfants Malades, Inserm, Institut Pasteur, Université Paris Cité, Institut Necker Enfants Malades, Assistance Publique – Hôpitaux de Paris, Institut de Pharmacologie Moléculaire et Cellulaire
- OJOlivier Join‐Lambert
Délégation Paris 5, Hôpital Necker-Enfants Malades, Inserm, Institut Pasteur, Université Paris Cité, Institut Necker Enfants Malades, Assistance Publique – Hôpitaux de Paris, Institut de Pharmacologie Moléculaire et Cellulaire
Topics & keywords
- Extravasation
- Leukocyte extravasation
- Immune system
- Monocyte
- Immunology
- Chemokine
- Population
- Patrolling
- Good health and well-being