Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
University of Minnesota · Twin Cities Orthopedics
Abstract
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage. The goal of the present study was to directly quantify the biological sources of hepatic and plasma lipoprotein TAG in NAFLD. Patients (5 male and 4 female; 44 +/- 10 years of age) scheduled for a medically indicated liver biopsy were infused with and orally fed stable isotopes for 4 days to label and track serum nonesterified fatty acids (NEFAs), dietary fatty acids, and those derived from the de novo lipogenesis (DNL) pathway, present in liver tissue and lipoprotein TAG. Hepatic and lipoprotein TAG fatty acids were analyzed by gas chromatography/mass…
Citation impact
- FWCI
- 37.49
- Percentile
- 100%
- References
- 50
Authors
6Topics & keywords
- Internal medicine
- Lipogenesis
- Nonalcoholic fatty liver disease
- Endocrinology
- Fatty liver
- Hypertriglyceridemia
- Very low-density lipoprotein
- Lipoprotein
- Good health and well-being