Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
Spanish National Centre for Cardiovascular Research · Hospital Universitario de La Princesa · +1 more institution
Abstract
Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells. However, the mechanisms that control the specific loading of RNA species into exosomes remain unknown. Here we describe sequence motifs present in miRNAs that control their localization into exosomes. The protein heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) specifically binds exosomal miRNAs through the recognition of these motifs and controls their loading into exosomes. Moreover, hnRNPA2B1 in exosomes is sumoylated, and sumoylation…
Citation impact
- FWCI
- 38.88
- Percentile
- 100%
- References
- 48
Authors
10- CVCarolina Villarroya‐BeltriCorresponding
Spanish National Centre for Cardiovascular Research
- CGCristina Gutiérrez‐Vázquez
Spanish National Centre for Cardiovascular Research
- FSFátima Sánchez‐Cabo
Spanish National Centre for Cardiovascular Research
- DPDaniel Pérez-Hernández
Spanish National Centre for Cardiovascular Research
- JVJesús Vázquez
Spanish National Centre for Cardiovascular Research
Topics & keywords
- Microvesicles
- microRNA
- Heterogeneous nuclear ribonucleoprotein
- SUMO protein
- Cell biology
- RNA
- Biology
- RNA-binding protein