ERK1/2 MAP kinases in cell survival and apoptosis
The University of Texas MD Anderson Cancer Center · SignalRx Pharmaceuticals (United States)
Indexed incrossrefpubmed
Abstract
ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.
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656
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Authors
2Topics & keywords
Topics
Keywords
- Kinase
- Mitogen-activated protein kinase
- Apoptosis
- Cell biology
- Phosphatase
- Subfamily
- MAPK/ERK pathway
- Biology
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