Iron Oxide Nanoparticles for Sustained Delivery of Anticancer Agents
University of Nebraska–Lincoln · University of Nebraska Medical Center
Abstract
We have developed a novel water-dispersible oleic acid (OA)-Pluronic-coated iron oxide magnetic nanoparticle formulation that can be loaded easily with high doses of water-insoluble anticancer agents. Drug partitions into the OA shell surrounding iron oxide nanoparticles, and the Pluronic that anchors at the OA-water interface confers aqueous dispersity to the formulation. Neither the formulation components nor the drug loading affected the magnetic properties of the core iron oxide nanoparticles. Sustained release of the incorporated drug is observed over 2 weeks under in vitro conditions. The nanoparticles further demonstrated sustained intracellular drug retention relative to drug in solution and a…
Citation impact
- FWCI
- 22.71
- Percentile
- 100%
- References
- 27
Authors
5- TKTapan K. JainCorresponding
University of Nebraska–Lincoln, University of Nebraska Medical Center
- MAMarco A. Morales
University of Nebraska Medical Center, University of Nebraska–Lincoln
- SKSanjeeb Kumar Sahoo
University of Nebraska Medical Center, University of Nebraska–Lincoln
- DLDiandra L. Leslie‐Pelecky
University of Nebraska–Lincoln, University of Nebraska Medical Center
- VLVinod Labhasetwar
University of Nebraska–Lincoln, University of Nebraska Medical Center
Topics & keywords
- Poloxamer
- Iron oxide nanoparticles
- Nanoparticle
- Chemistry
- Magnetic nanoparticles
- Drug delivery
- Drug
- Iron oxide