Bone Morphogenetic Protein (BMP) signaling in development and human diseases
University of Chicago · Molecular Oncology (United States) · +3 more institutions
Abstract
Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce bone formation, BMPs are now known to play crucial roles in all organ systems. BMPs are important in embryogenesis and development, and also in maintenance of adult tissue homeostasis. Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects, highlighting the essential functions of BMPs. In this review, we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the…
Citation impact
- FWCI
- 20.91
- Percentile
- 100%
- References
- 311
Authors
20- RNRichard N. Wang
University of Chicago, Molecular Oncology (United States), University of Chicago Medical Center
- JJJordan J. Green
University of Chicago, Molecular Oncology (United States), University of Chicago Medical Center
- ZWZhongliang Wang
University of Chicago Medical Center, Chongqing Medical University, Molecular Oncology (United States)
- YDYoulin Deng
Molecular Oncology (United States), Chongqing Medical University, University of Chicago Medical Center
- MQMin Qiao
Molecular Oncology (United States), Chongqing Medical University, University of Chicago Medical Center
Topics & keywords
- Bone morphogenetic protein
- BMPR2
- Biology
- Cell biology
- Knockout mouse
- Signal transduction
- Bone morphogenetic protein 7
- Embryonic stem cell
- Good health and well-being