Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development
Centre National de la Recherche Scientifique · Howard Hughes Medical Institute · +3 more institutions
Abstract
The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM…
Citation impact
- FWCI
- 24.46
- Percentile
- 100%
- References
- 39
Authors
5- IOIkuhiro Okamoto
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, Amsterdam University of Applied Sciences, Institut Curie, Rockefeller University
- APArie P. Otte
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, Amsterdam University of Applied Sciences, Institut Curie, Rockefeller University
- CDC. David Allis
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, Amsterdam University of Applied Sciences, Institut Curie, Rockefeller University
- DRDanny Reinberg
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, Amsterdam University of Applied Sciences, Institut Curie, Rockefeller University
- ÉHÉdith HeardCorresponding
Centre National de la Recherche Scientifique, Howard Hughes Medical Institute, Amsterdam University of Applied Sciences, Institut Curie, Rockefeller University
Topics & keywords
- Reprogramming
- Epigenetics
- X-inactivation
- Genomic imprinting
- Histone
- Biology
- Cell biology
- Embryo