Neural basis of global resting-state fMRI activity
National Institutes of Health · National Institute of Mental Health · +4 more institutions
Abstract
Functional MRI (fMRI) has uncovered widespread hemodynamic fluctuations in the brain during rest. Recent electroencephalographic work in humans and microelectrode recordings in anesthetized monkeys have shown this activity to be correlated with slow changes in neural activity. Here we report that the spontaneous fluctuations in the local field potential (LFP) measured from a single cortical site in monkeys at rest exhibit widespread, positive correlations with fMRI signals over nearly the entire cerebral cortex. This correlation was especially consistent in a band of upper gamma-range frequencies (40-80 Hz), for which the hemodynamic signal lagged the neural signal by 6-8 s. A strong, positive correlation was…
Citation impact
- FWCI
- 25.86
- Percentile
- 100%
- References
- 58
Authors
5- MLMarieke L. Schölvinck
National Institutes of Health, National Institute of Mental Health, National Institute of Mental Health, University College London
- AMAlexander Maier
National Institutes of Health, National Institute of Mental Health
- FQFrank Q. Ye
National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, National Institute of Mental Health
- JHJeff H. Duyn
National Institutes of Health, National Institute of Neurological Disorders and Stroke
- DADavid A. LeopoldCorresponding
National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, National Institute of Mental Health
Topics & keywords
- Resting state fMRI
- Local field potential
- Neuroscience
- Neural activity
- Functional magnetic resonance imaging
- Electroencephalography
- Brain activity and meditation
- Nuclear magnetic resonance