Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis

CONTEXT: Low testosterone levels have been associated with outcomes that reduce survival in men. OBJECTIVE: Our objective was to perform a systematic review and meta-analysis of published studies to evaluate the association between endogenous testosterone and mortality. DATA SOURCES: Data sources included MEDLINE (1966 to December 2010), EMBASE (1988 to December 2010), and reference lists. STUDY SELECTION: Eligible studies were published English-language observational studies of men that reported the association between endogenous testosterone and all-cause or cardiovascular disease (CVD) mortality. A two-stage process was used for study selection. 1) Working independently and in duplicate, reviewers screened…

• EL
  Eli Lilly and Company
• NE
  New England Research Institutes
• NI
  National Institutes of Health
• MR
  Medical Research Council
• AR
  Australian Research Council
• NH
  National Health and Medical Research Council
• NI
  National Institute on Aging