General Anesthesia, Sleep, and Coma

Brown, Emery N.; Lydic, Ralph; Schiff, Nicholas D.

doi:10.1056/nejmra0808281

reviewNew England Journal of MedicineDec 29, 2010GREEN OA

General Anesthesia, Sleep, and Coma

ENEmery N. Brown RLRalph Lydic NDNicholas D. Schiff

Harvard University · Harvard–MIT Division of Health Sciences and Technology · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

This review discusses the clinical and neurophysiological features of general anesthesia and their relationships to sleep and coma, focusing on the neural mechanisms of unconsciousness induced by selected intravenous anesthetic drugs.

Citation impact

1,330

total citations

FWCI: 24.06
Percentile: 100%
References: 106

Citations per year

Authors

EN
Emery N. BrownCorresponding
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Massachusetts General Hospital
RL
Ralph Lydic
University of Michigan–Ann Arbor
ND
Nicholas D. Schiff
Cornell University

Topics & keywords

Topics

Sleep and Wakefulness Research100%
Anesthesia and Neurotoxicity Research100%
Anesthesia and Sedative Agents100%

Keywords

Unconsciousness
Coma (optics)
Anesthesia
Anesthetic
Sleep (system call)
Medicine
Computer science

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

JS
James S. McDonnell Foundation
MG
Massachusetts General Hospital
UO
University of Michigan
NI
National Institutes of Health
Awards: HL65272, HL40881, HD51912