Microbiota disbiosis is associated with colorectal cancer
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Abstract
The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent non-cancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance…
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556
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- FWCI
- 17.62
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- 100%
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Authors
5Topics & keywords
Topics
Keywords
- Fusobacteria
- Firmicutes
- Dysbiosis
- Fusobacterium
- Colorectal cancer
- Biology
- Gut flora
- Proteobacteria
UN Sustainable Development Goals
- Good health and well-being
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