DNA methylation controls Foxp3 gene expression
Zero to Three · Charité - Universitätsmedizin Berlin · +3 more institutions
Abstract
Compelling evidence suggests that Foxp3-expressing CD25(+)CD4(+) regulatory T cells (Treg) are generated within the thymus as a separate lineage. However, Foxp3(+)CD4(+) Treg can also be generated de novo in a TGF-beta-dependent process from naive T cells by TCR triggering. Recently, we have shown that naturally occurring, but not in vitro TGF-beta-induced Foxp3(+) Treg display stable Foxp3 expression that was associated with selective demethylation of an evolutionarily conserved element within the Foxp3 locus named TSDR (Treg-specific demethylated region). Here, we report that inhibition of DNA methylation by azacytidine, even in absence of exogenous TGF-beta, not only promoted de novo induction of Foxp3…
Citation impact
- FWCI
- 14.48
- Percentile
- 100%
- References
- 50
Authors
10- JKJulia K. Polansky
Zero to Three, Charité - Universitätsmedizin Berlin
- KKKarsten Kretschmer
Harvard University, Dana-Farber Cancer Institute, Zero to Three, Technische Universität Dresden
- JFJennifer Freyer
Charité - Universitätsmedizin Berlin
- SFStefan Floess
Charité - Universitätsmedizin Berlin
- AIAnnette I. Garbe
Harvard University, Dana-Farber Cancer Institute, Technische Universität Dresden
Topics & keywords
- FOXP3
- DNA methylation
- Epigenetics
- Demethylation
- Biology
- Methylation
- DNA demethylation
- In vitro