Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus
Centers for Disease Control and Prevention · J. Craig Venter Institute · +1 more institution
Abstract
Vancomycin is usually reserved for treatment of serious infections, including those caused by multidrug-resistant Staphylococcus aureus. A clinical isolate of S. aureus with high-level resistance to vancomycin (minimal inhibitory concentration = 1024 microg/ml) was isolated in June 2002. This isolate harbored a 57.9-kilobase multiresistance conjugative plasmid within which Tn1546 (vanA) was integrated. Additional elements on the plasmid encoded resistance to trimethoprim (dfrA), beta-lactams (blaZ), aminoglycosides (aacA-aphD), and disinfectants (qacC). Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies…
Citation impact
- FWCI
- 23.92
- Percentile
- 100%
- References
- 19
Authors
10- LMLinda M. WeigelCorresponding
Centers for Disease Control and Prevention, J. Craig Venter Institute, University of Michigan
- DBDon B. Clewell
Centers for Disease Control and Prevention, J. Craig Venter Institute, University of Michigan
- SRSteven R. Gill
Centers for Disease Control and Prevention, J. Craig Venter Institute, University of Michigan
- NCNancye C. Clark
Centers for Disease Control and Prevention, J. Craig Venter Institute, University of Michigan
- LKLinda K. McDougal
Centers for Disease Control and Prevention, J. Craig Venter Institute, University of Michigan
Topics & keywords
- Staphylococcus aureus
- Vancomycin
- Microbiology
- Plasmid
- Enterococcus faecalis
- Biology
- Bacteria
- Genetics
- Good health and well-being